Publications
In the past, we covered various health- and longevity-related topics with a dedicated team of researchers and produced a range of high-quality analyses.
However, each analysis took us more than two months with a team of two. And it was even more time-consuming to train new team members. This neither scaled to cover all potential interventions nor to keep past reviews up to date at all times. So basically, we knew what we wanted, and we learned the challenges. But it turned out to be impractical to do it the conventional way.
Luckily, we are now entering the age of modern AIs that have potentially ingested all research papers ever published, heard everything ever said, and seen every video about a certain topic.
AI4L - AI for Practical Longevity is our approach to shaping leading-edge AI into a useful tool for personal health and longevity for everyone.
Publications from our “Maximizing Health” Initiative:
Our research team looked into advanced medical topics that we found helpful to optimize our health and well-being.
Numerous aspects of lipid metabolism have been implicated in the development of cardiovascular disease. Therefore, it is essential to identify biomarkers that allow reliable cardiovascular risk prediction. This Practical Guide aims to identify these markers, evaluate their relevance, and determine the most appropriate lipid-monitoring protocol.
APOE is the gene that codes for Apolipoprotein E, a key player in our lipid metabolism. The APOE4 variant is well known for its association with a significantly higher risk of Alzheimer's disease. Numerous other conditions have been linked to it, including different forms of dementia, cardiovascular disease, and decreased longevity. There are several important implications for carriers of one or two copies of the E4 variant, particularly concerning saturated fat and heavy metal detox.
Our practical guide covers the inherent risks and strategies to minimize their impact.
Numerous natural antivirals and immunomodulators have been proposed for the prevention and treatment of COVID-19. In this "Practical Guide," we review the scientific, empirical, and clinical evidence for 50 natural substances and mixtures that may help prevent infection or reduce symptom severity.
Publications from our "Rejuvenation Now" Initiative
The team set out to identify potential rejuvenation therapies and systematically evaluate their risks, benefits, and associated therapeutic protocols to create transparency.
Skin Rejuvenation by Low-Level Light Therapy
Low-level light therapy, or photobiomodulation, is the use of low-energy light at specific wavelengths to influence cellular processes. Targeting the skin, it is supposed to lead to a more youthful appearance through increased collagen and elastin production and a reduction in age spots and wrinkles.
Fisetin is a flavonoid found in many fruits and vegetables and is readily available over the counter as a supplement. When used intermittently at high doses, it is intended to act as a senolytic agent to remove senescent cells, offering an easily accessible, inexpensive therapeutic option.
Vascular Rejuvenation using EDTA
EDTA chelation therapy is the use of EDTA, a synthetic amino acid, to remove unwanted metals from the body. Observed "side effects" include rejuvenation of the cardiovascular system and a substantial reduction of adverse cardiovascular events such as heart attack and stroke. Proposed mechanisms include stabilization and reduction of atherosclerotic plaque, prevention of epigenetic changes, and stabilization of membranes.
NAD+ is a nucleotide found in all living cells that plays an important role in energy metabolism. Levels may decline markedly with age, and restoring them to a youthful state using various oral precursors, transdermal patches, or IVs is believed to have beneficial effects on health and longevity.
Centrophenoxine is a compound consisting of DMAE and para-chlorophenoxyacetic acid. DMAE can be converted by cells into choline, a precursor of membrane phospholipids, neurotransmitters, and other important biomolecules. The acid component enhances penetration across the blood-brain barrier.
Centrophenoxine supplementation is hypothesized to increase brain acetylcholine levels, protect neurons from oxidative damage, and improve cognitive function. Additionally, it is said to reduce the accumulation of lipofuscin, a non-degradable, toxic byproduct of metabolism and a potential root cause for several age-related diseases.
Phospholipids are important structural components of cell and organelle membranes and play roles in many cell signaling pathways. Membranes incur oxidative damage over time and in several disease conditions. Oral and/or i.v. supplementation of phospholipids (particularly phosphatidylcholine) is hypothesized to repair this damage by replacing oxidized membrane phospholipids with "healthy" phospholipids, thus restoring or maintaining membrane integrity and function.
Dasatinib and Quercetin Senolytic Therapy
Dasatinib is a well-established medication used in the treatment of cancer. Quercetin is a flavonoid found in many plants and foods that is often used as a supplement. It is expected that intermittent dosing of D+Q eliminates senescent cells in humans and, in doing so, has the potential to prevent, delay, or alleviate multiple age-related diseases and increase healthy lifespan.