Rejuvenation Now
- Service Confluence Forever-Healthy
- Michael Greve
Forever Healthy's "Rejuvenation Now" initiative seeks to continuously identify potential rejuvenation therapies and systematically evaluate their risks, benefits, and associated therapeutic protocols to create transparency.
Currently available Risk-Benefit Analyses
Skin Rejuvenation by Low-Level Light Therapy
Low-level light therapy or photobiomodulation is the use of low-energy light at a particular wavelength to influence cellular processes. Targeting the skin, it is supposed to lead to a more youthful appearance through increased collagen and elastin production and a reduction in age spots and wrinkles.
Fisetin is a flavonoid found in many types of fruits and vegetables that is readily available over the counter as a supplement. Used intermittently at high doses, it is supposed to act as a senolytic agent to remove senescent cells, presenting an easily accessible, inexpensive therapeutic option.
Vascular Rejuvenation using EDTA
EDTA chelation therapy is the use of EDTA, a synthetic amino acid, to remove unwanted metals from the body. Observed "side effects" include rejuvenation of the cardiovascular system and a substantial reduction of adverse cardiovascular events such as heart attack and stroke. Proposed mechanisms include the stabilization and reduction of atherosclerotic plaque, prevention of epigenetic changes, and stabilization of membranes.
NAD+ is a nucleotide found in all living cells that play an important role in energy metabolism. Levels may decline markedly with age, and restoring them to a youthful state using various oral precursors, transdermal patches, or IVs is believed to have beneficial effects on health and longevity.
Centrophenoxine
Centrophenoxine is a compound consisting of DMAE and para-chlorophenoxyacetic acid. DMAE can be converted by cells into choline, a precursor of membrane phospholipids, neurotransmitters, and other important biomolecules. The acid component enhances penetration across the blood-brain barrier.Centrophenoxine supplementation is hypothesized to increase brain acetylcholine levels, protect neurons from oxidative damage, and improve cognitive function. Additionally, it is said to reduce the accumulation of lipofuscin, a non-degradable, toxic byproduct of metabolism and a potential root cause for several age-related diseases.
Phospholipid Therapy
Phospholipids are an important structural component of cell and organelle membranes and play a role in many cell signaling pathways. Membranes incur oxidative damage over time and in several disease conditions. Oral and/or i.v. supplementation of phospholipids (particularly phosphatidylcholine), is hypothesized to repair this damage by replacement of oxidized membrane phospholipids with "healthy" phospholipids, thus restoring or maintaining membrane integrity and function.
Dasatinib and Quercetin Senolytic Therapy
Dasatinib is a well-established medication used in the treatment of cancer. Quercetin is a flavonoid found in many plants and foods that is often used as a supplement. It is supposed that intermittent dosing of D+Q leads to the elimination of senescent cells in humans and by doing so, has the potential to prevent, delay, or alleviate multiple age-related diseases and increase the healthy lifespan.
Get notified by mail when a new publication is released
Upcoming work
Peptide Therapy for Hair Regrowth
Use of PDT-DBM polypeptide to stimulate scalp hair regrowth
Open for Collaboration
The "Rejuvenation Now" initiative is set up as an international collaboration of scientists, doctors, and the foundation. If you would like to collaborate, just leave us a note.