Centrophenoxine - Table 3: Herrschaft Summary

Dementia studies from Herrchaft, 1992 not available online:

Category	Benefit	Publication	Pre-existing conditions	Inpatient/outpatient	Number of participants	Participant age	Treatment duration (weeks)	Daily dose (mg)	Physician's assessment	Changes in symptoms	Self-assessment	Performance tests	Additional info

Category	Benefit	Publication	Pre-existing conditions	Inpatient/outpatient	Number of participants	Participant age	Treatment duration (weeks)	Daily dose (mg)	Physician's assessment	Changes in symptoms	Self-assessment	Performance tests	Additional info
Cognitive Psychiatric Musculoskeletal	↑ memory of unspecific type ↑ behavior and mood ↓ stiff shoulder	Ichimaru S, Kudo Y, Itoh M, Vejima T et al. (1973) Double-blind controlled trial of meclofenoxate (lucidril tablet) on cerebral arteriosclerosis. Igaku no Ayumi 114: 456–464	VaD	mixed	222	>60	4	600-1200	NA	memory affective lability stiff shoulder all improved significantly (p<0.05)	NA	NA
CNS, Cognitive	↑ memory of unspecific type ↓ headache after head injury or cerebrovascular disease ↓ dizziness	Schilter R (1974) Zur Wirkung von Cerutil (Centrophenoxin) bei zerebralsklerotischen Patienten. Z Altersforsch 28: 231–238	VaD	inpatient	25	79 (average)	6	900-600 (dose reduction)	improved (p<0.01)	headache memory dizziness all improved significantly (p<0.01)	NA	not significant
Cerebrovascular	↑ general clinical improvement in chronic cerebrovascular disease	Zdichynec B (1975) Klinische Erfahrungen bei der peroralen Therapie von manifesten Formen zerebraler Atherosklerose. Ars Medici 65: 475–478	VaD	likely inpatient	160	58-68	6	500	improved (p<0.05)	NR	NA	NR	(comparator: procaine)
Cognitive	↑ general clinical improvement in dementia and intellectual deterioration	Ankerhold W (1975) Therapeutische Cerutil-Effekte bei intellektuell minderbefähigten, vorwiegend hirngeschädigten Kindern und bei Erwachsenen mit senilen Rückbildungsvorgängen und hirninvolutiven zerebralen Leistungsschwächen. Medicamentum (Berlin) 16: 136–137	mild-moderate senile dementia (Alzheimer's disease)	inpatient	36	70 (average)	6	1000	% improved: CPH: 58 placebo: 42	NR	NR	NR
Psychiatric	↑ behavior and mood	Bonnes B, Kuchenbuch S (1978) Untersuchungen mit Cerutil im Doppelblindversuch bei Patienten mit überforderungssyndrom und eventuellen leichten Involutionserscheinungen. Medicamentum (Berlin) 19: 262–264	overwork syndrome with emotional deficits	outpatient	250	up to 65	4-5	600	% improved: CPH: 60 placebo: 40	NR	NR	not significant
Cognitive	↑ long-term memory and learning ↑ general clinical improvement in dementia and intellectual deterioration (conflict/+ trend only)	Morton O, Goldberg A (1984) A multi-centre trial of meclofenoxate in the treatment of chronic brain syndrome. Publikationsmanuskript. Promonta GmbH, Hamburg	senile dementia (Alzheimer's disease)	inpatient	62	78/80	12 months	1200	positive trend only	NA	NA	incidental learning test (p<0.05)