Centrophenoxine - Table 4: Benefits

Owned by Service Confluence Forever-Healthy
Jan 18, 2024



Category Benefit type 

Magnitude

Likelihood

Duration

Importance to patientSummaryWeightScoreUncertaintyWeighted score
1Dementia & cognitive decline↑ clinical improvement/stabilization in dementia & cognitive decline

1

2

1

2

61.5+1

1 RCT: Marcer & Hopkins, 1977; Pieschl et al., 1983; Vehreschild et al., 1975

2 Comparative/Open-label: Popa et al., 1994; Yang, 2015; Yang & Zhang, 2016; Herrschaft, 1992; Zhou, 2002

3 Observational: Tamai & Torii, 1990

Conflict: Bower & McDonald, 1966; Pék et al., 1989

0.75
2Dementia & cognitive decline
↑ ADL in dementia & cognitive decline
1

 

1

 

1

 

2

 

51.25+1

1 RCT: Marcer & Hopkins, 1977

2 Open-label: Fu et al., 2007

Conflict: Zhang & Wang, 2007; Pék et al., 1989; Bower & McDonald, 1966

0
3Dementia & cognitive decline↑ clinical improvement in corpus callosum degeneration

1

2

1

3

7
1.75
+1

2 Open-label: Dai & Li, 2012

0.5
4Dementia & cognitive decline↓ neurological deficit in VaD

1

2

1

3

71.75+1

1 RCT: Bian et al., 2004

2 Comparative: Chen, 2007b; Yao et al., 2006

1.25
5Dementia & cognitive decline↑ clinical improvement in VaD

1

2

1

3

71.75+1

1 RCT: Bian et al., 2004

2 Comparative/Open-label: Niu & Li, 2008; Fu et al., 2007; Zhang & Wang, 2007; Herrschaft, 1992

3 Observational: Tamai & Torii, 1990; Richter, 1983; Ma, 2014

1.25
6General↑ CBF

1

3

1

2

71.75+1

2 Comparative/Open-label: Herrschaft et al., 1974; Chen, 2010; Herrschaft, 1992

1
7General↑ clinical improvement in chronic cerebrovascular disease

1

1

1

 

1

 

41+1

2 Comparative: Wasilewski et al., 1981

0
8Metabolism & biochemistry↓ age-related intracellular water loss

1

1

1

1

41+1

1 RCT: Fülöp et al., 1990

0.75
9Metabolism & biochemistry

↑ blood oxygen saturation & consumption

1

1

1

1

41+12 Comparative/Open-label: Tang & Dong, 2018; Schmid & Schlick, 1979

Conflict: Xie & Min, 2013

0
10Metabolism & biochemistry↓ fasting glucose levels

1

1

1

1

41+1

2 Open-label: Schmid & Schlick, 1979

0
11Metabolism & biochemistry↑ normalization of blood glucose dynamics

1

1

1

1

41+1

2 Comparative: Stoica et al., 1974

0
12Metabolism & biochemistry↑ oxidative stress mitigation

2

1

1

1

51.25+1
1 RCT: Zheng et al., 2011
2 Comparative: Tang & Dong, 2018
1.25
13Metabolism & biochemistry↑ energy

1

1

1

1

41+1
2 Open-label: Vojtechovsky et al., 1969
0
14Metabolism & biochemistry

↑ biomarkers in cerebrovascular disease

2

 

1

1

2

6
1.5
+1

1 RCT: Zhang, 2018b; Hou et al., 2019; Ji et al., 2007

3 Observational: You, 2020

1.5
15Movement disorders↑ reflexes in cerebral palsy

1

1

1

2

51.25+1

2 Open-label: Bradna, 1967

0
16Movement disorders↓ involuntary movements in tardive dyskinesia

2

2

2

2

82+1

2 Open-label: Izumi et al., 1986

Conflict: Yagi et al., 1990 

0
17Movement disorders↓ ALS symptoms

1

1

1

2

51.25+1

2 Comparative: Sercl & Kovarik, 1963

0
18Musculoskeletal↑ bone mineral density

1

1

1

1

41+1

2 Comparative: Li et al., 2019

0
19Musculoskeletal↓ shoulder stiffness

1

1

1

1

41+1

2 Open-label: Herrschaft, 1992 

Conflict: Hasegawa et al., 1976; Itoh et al., 1968

0
20Neurological symptoms↓ ischemia-induced orthostatic hypotension & abnormal catecholamine response

1

1

1

1

41+1

2 Open-label: Stoica & Enulescu, 1991

0

21Neurological symptoms↓ dizziness

1

2

1

2

61.5+1

1 RCT: Itoh et al., 1968

2 Open-label: Herrschaft, 1992

3 Observational: Zhao, 2004

1.5
22Neurological symptoms↓ headache

1

2

1

2

61.5+1

2 Open-label: Lin, 2001; Herrschaft, 1992

3 Observational: Zhao, 2004

Conflict: Itoh et al., 1968

0
23Neurological symptoms↑ HRV in ACI

1

1

1

2

5
1.25
+1

2 Comparative: Liu et al., 2008

0
24Neurological symptoms↓ vertigo

1

1

1

2

5
1.25
+1

2 Comparative: Chen, 2007a

0
25Neurological symptoms↓ visually-triggered gaze saccade latency in post-traumatic cervical syndrome

2

2

1

1

6
1.5
+1

2 Open-label: Maeda & Ishii, 1984

0
26Neurological symptoms↑ clinical improvement in cortical blindness

1

1

1

2

5
1.25
+1

3 Observational: Yang & Feng, 1987

0
27Perinatal & pediatric↑ long-term memory & learning in children

1

1

1

2

51.25+1

2 Open-label: Herrschaft, 1992

Conflict: Teichmann & Schwebke, 1973

0
28Perinatal & pediatric↑ general cognition & mental performance in children

1

2

1

2

61.5+1

2 Open-label: Herrschaft, 1992; Colpin, 1970

Conflict: Teichmann & Schwebke, 1973

0
29Perinatal & pediatric↑ behavior & mood in children

1

1

1


1
4
1
+1

2 Open-label: Herrschaft, 1992; Colpin, 1970

Conflict: Kirman, 1961; Teichmann & Schwebke, 1973

0
30Perinatal & pediatric
↑ clinical improvement in HIE

1


2

2

3

82+1

1 RCT: Guo, 2013; Pu & Liu, 2008; Xiang & Wang, 2005; Wang, 2011; Fang et al., 2010; Hui & Zhang, 2022

2 Comparative: Wu, 2010

1.5
31Perinatal & pediatric↑ condition of the newborn in SGA fetuses

2

2

2

2

8
2
+1

1 RCT: Neumann & Zienert, 1993

1.75
32Perinatal & pediatric↓ clinical symptoms in pediatric enuresis

1

2

1

1

5

1.25+1

2 Comparative: Zhang et al., 2021; Ma et al., 2020; Zhang, 2018a; Li & Kang, 2017; Wang, 2015; Jiang et al., 2014; Chen et al., 2013; Shi et al., 2013; Dong et al., 2012; Mao, 2009; Zhang et al., 2009; Ding et al., 2007; Zhang & Zhang, 2017; Zhu et al., 2003b; Wang, 2020; Li, 2010; Wang, 2009; Yu et al., 2020; Hu et al., 2008

Conflict: Kirman, 1961

1
33Perinatal & pediatric↓ sleep arousal threshold in pediatric enuresis

1

1

1

1

4

1
+1

2 Comparative: Hu et al., 2008; Ma et al., 2020; Wang, 2020

0
34Poisoning & anesthesia↑ recovery in acute severe organophosphate poisoning

2

2

2

3

9
2.25
+1

1 RCT: Huang & Zhang, 2006; Li, 2009

1.5
35Poisoning & anesthesia↑ clinical improvement in alcohol intoxication

2 

1

1

1

5
1.25
+1

1 RCT: Liao, 2019; Shi, 2017; Hu et al., 2013; Yang & Li, 2012; Sun et al., 2010 (identical data in Xu et al., 2014); Wu & Zhang, 2008; Mai, 2013; Ji, 2009

2 Comparative: Tang & Dong, 2018; Huang, 2011; Chen et al., 2006; Hou, 2009

1
36Poisoning & anesthesia↓ awakening time in alcohol intoxication

2

1

1

2

6
1.5
+1

1 RCT: Shi, 2017; Liao, 2019; Hu et al., 2013; Sun et al., 2010 (identical data in Xu et al., 2014); Yang & Li, 2012; Ji, 2009

2 Comparative: Huang, 2011; Chen et al., 2006

1.5
37Poisoning & anesthesia↓ duration & severity of acute delirium in alcohol withdrawal

2

1

1

2

6
1.5
+1

2 Open-label: Herrschaft, 1992 

0.5
38Poisoning & anesthesia↑ clinical improvement in CO poisoning

1

1

1

3

6
1.5
+1

1 RCT: Zheng et al., 2011; Lv & Yuan, 2010; Hou, 2010

1
39Poisoning & anesthesia↑ recovery from general anesthesia

1

1

1

1

41+1

1 RCT: Mao et al., 2019; Mao, 2013

0.75
40Psychiatry & psychology↑ improvement/stabilization in attention & concentration

1

1

1

2

51.25+1

1 RCT: Pieschl et al., 1983; Vehreschild et al., 1975; Vojtechovsky et al., 1970

2 Comparative/Open-label: Popa et al., 1994; Molčan et al., 1978

Conflict: Oliver & Restell, 1967; Bower & McDonald, 1966

1
41Psychiatry & psychology↑ short-term memory

1

1

1

2

51.25+1

1 RCT: Vojtechovsky et al., 1970

2 Open-label: Molčan et al., 1978

Conflict: Marcer & Hopkins, 1977; Pék et al., 1989; Oliver & Restell, 1967; Harris & Dowson, 1986; Vojtechovsky et al., 1970

0
42Psychiatry & psychology↑ long-term memory & learning

2

2

1

2

71.75+1

1 RCT: Marcer & Hopkins, 1977; Gedye et al., 1972; Vojtechovsky et al., 1970

2 Comparative/Open-label: Vojtechovsky et al., 1969; Herrschaft, 1992; Popa et al., 1994

Conflict: Pék et al., 1989; Oliver & Restell, 1967; Harris & Dowson, 1986

1
43Psychiatry & psychology↑ memory of unspecific type

1

2

1

2

61.5+1

2 Comparative/Open-label: Zhou, 2002; Herrschaft, 1992

3 Observational: Zhao, 2004

Conflict: Itoh et al., 1968

0
44Psychiatry & psychology↑ general cognition & mental performance

2

2

1

2

71.75+1

1 RCT: Zhu et al., 2003a; Hou et al., 2019

2 Comparative/Open-label: Popa et al., 1994; Yao et al., 2006; Zhou, 2002; Chen, 2007b; Fu et al., 2007; Zhang & Wang, 2007; Herrschaft, 1992

Conflict: Pék et al., 1989; Bower & McDonald, 1966; Harris & Dowson, 1986

1
45

Psychiatry & psychology

↓ depression

2

1

1

2

6
1.5
+1

1 RCT: Xing et al., 1996; Tang & Zhou, 2006

3 Observational: Qiu & Zhang, 2003

Conflict: Bian et al., 2006

0.25
46

Psychiatry & psychology 

↑ behavior & mood

1

1

1

2

5
1.25
+1

2 Comparative/Open-label: Popa et al., 1994; Zhou, 2002; Molčan et al., 1978; Herrschaft, 1992

3 Observational: Tamai & Torii, 1990

Conflict: Pék et al., 1989; Bower & McDonald, 1966; Itoh et al., 1968; Hasegawa et al., 1976

0.25
47

Psychiatry & psychology

↓ neuroses

1

1

1

2

5
1.25
+1

1 RCT: Pieschl et al., 1983

Conflict: Ziolko, 1961

0.25
48Sleep & consciousness↑ favorable sleep changes

1

2

1

2

6
1.5
+1

2 Open-label: Ti et al., 2002

3 Observational: Wan & Bao, 1985

Conflict: Bower & McDonald, 1966; Brezinova et al., 1970

0
49Sleep & consciousness

↑ EEG vigilance and SSEP amplitudes

1

1


1


1


4
1
1

2 Comparative/Open-label: Kinoshita, 1990; Herrschaft, 1992; Brezinova et al., 1970; Umlauf et al., 1983

0
50Stroke

↓ neurological deficit in ACH

2

1

2

3

8
2
+1

1 RCT: Lu et al., 2007; Zhang, 2018b; Lv & Huang, 2008; Ma & Zhou, 2021

3 Observational: You, 2020

1.5
51Stroke

↓ neurological deficit in ACI

1

2

2

3

7
1.75
+1

1 RCT: Lu et al., 2006; Ji et al., 2007; Dai et al., 2009; Lin, 2014; Chen et al., 2003

Conflict: Bian et al., 2006

1.5
52Stroke

↓ volume of brain edema in ACH

2

1

2

3

8
2
+1

1 RCT: Zhang, 2018b; Hou et al., 2019

1.5
53Stroke

↑ clinical improvement in ACH

1

2

1

3

7
1.75
+1

1 RCT: Lv & Huang, 2008; Hou et al., 2019; Zhang, 2018b; Ma & Zhou, 2021; Cooperation Study Group on Acute Cerebrovascular Diseases, 1978

1.5
54Stroke

↑ clinical improvement in cerebral infarction

1

2

1

3

7
1.75
+1

1 RCT: Wang & He, 2007; Lin, 2014

2 Comparative/Open-label: Stoica et al., 1974; Liang & Wang, 2012; Herrschaft, 1992

Conflict: Cooperation Study Group on Acute Cerebrovascular Diseases, 1978

1.5
55Stroke

↑ clinical improvement in cerebrovascular disease of unspecified type

2

2

1

3

8
2
+1

2 Open-label: Budinova-Smela & Mimrova, 1975

3 Observational: Zhao, 2004

Conflict: Robinson, 1978; Hasegawa et al., 1976

0
56Stroke

↑ ADL in acute cerebral damage

2

1

2

2

71.75+1

1 RCT: Zhang, 2018b; Lu et al., 2006; Hou et al., 2019; Zhu et al., 2003a; Chen et al., 2003; Ji et al., 2007; Lin, 2014

3 Observational: You, 2020

1.5
57TBI & coma↑ consciousness level

2

2

2

 

3

92.25+1

1 RCT: Cooperation Study Group on Acute Cerebrovascular Diseases, 1978; Zhang, 2018b; Ma, 2018; Lu et al., 2007; Gao et al., 2008; Gao et al., 2006

2 Open-label: Umlauf et al., 1983

3 Observational: Bassem et al., 2018

Conflict: Cooperation Study Group on Acute Cerebrovascular Diseases, 1978; Hasegawa et al., 1976

1.75
58TBI & coma↑ recovery from TBI

1

2

2

3

8
2
+1

1 RCT: Ma, 2018; Guo et al., 2011

3 Observational: Han, 2005; Xing & Yang, 1991

Conflict: Itoh et al., 1968

1
59Urinary↓ clinical symptoms in enuresis

1

1

1

2

5

1.25+1

1 RCT: Zhu et al., 2003a; Bian et al., 2004

2 Comparative: Zhou et al., 2013; Bai et al., 2002

3 Observational: Zhu & Ren, 1997; Yan, 1990; Zhao, 2004

0.5


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