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","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Herrschaft, 1992","type":"text","marks":[{"type":"link","attrs":{"href":"https://link.springer.com/chapter/10.1007/978-3-7091-6400-6_55"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Colpin, 1970","type":"text","marks":[{"type":"link","attrs":{"href":"https://pubmed.ncbi.nlm.nih.gov/4394692/"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"Conflict: ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Kirman, 1961","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/10.1111/jir.1961.5.2.108"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":";","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":" 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","type":"text"},{"text":"Pu & Liu, 2008","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2008&filename=EKYX200804024&uniplatform=OVERSEAS_EN&v=eTtrJMhHSAV2G0q2zdwFVyX3tSUiXfvJF2SqFRZv3U7i7A99NJB1-jw7LtJipJAa"}}]},{"text":"; ","type":"text"},{"text":"Xiang & Wang, 2005","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2005&filename=YYCY200512031&uniplatform=OVERSEAS_EN&v=H3gr5aMjnEzJ4Ka1cLWrN2JKew_aYksOBaFBbQcXFS687Qxo2sd8qn8DIiNc6gyu"}}]},{"text":"; ","type":"text"},{"text":"Wang, 2011","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2011&filename=YYXK201128063&uniplatform=OVERSEAS_EN&v=dGiwO7Vt3nF8aTONIoKIktCg_7lPjxUV-sNwrh7keKIIBdlsyGTva-KHtnaxMojN"}}]},{"text":"; ","type":"text"},{"text":"Fang et al., 2010","type":"text","marks":[{"type":"link","attrs":{"href":"http://yuxiqbs.cqvip.com/Qikan/Article/Detail?id=33285822"}}]},{"text":"; ","type":"text"},{"text":"Hui & Zhang, 2022","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2022&filename=GWZW202203010&uniplatform=OVERSEAS_EN&v=aO4hH7I1Kaor9NJDLXHUAd-nAFMTImdZxYXY_r7ZYLtfx9Mq0fGeWPjnUVFG0PG6"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"2 Comparative: ","type":"text"},{"text":"Wu, 2010","type":"text","marks":[{"type":"link","attrs":{"href":"https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2010&filename=YYCY201011026&uniplatform=NZKPT&v=EuhNWEOXm-lXiS-EZQVinwCH6uIGPWV_6eFMl8fG54Fnd1_5PtIk6GiyBRh0PfOj"}}]}]},{"type":"paragraph","content":[{"text":"Not blinded (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"Only abstract (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"Too high 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1993","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/https://doi.org/10.1515/9783110848977-016"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Single study: -0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Not peer-reviewed: -0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Precautionary principle as it is during pregnancy and no other studies: -0.25","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":" 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2017","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2017&filename=HNZK201704046&uniplatform=OVERSEAS_EN&v=24fm3N7-B5ZA8x8LXMTICllv1SmhziUom7ZPVAV6RhDcO7FBnD8dBoNEG1SEgjhq"}}]},{"text":"; ","type":"text"},{"text":"Wang, 2015","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2015&filename=ZYEZ201501019&uniplatform=OVERSEAS_EN&v=zReSX6Abnvo7ZDQLhLUG97kgS1vsRZ2q88Po35D7QX96ujqNcEVDK6oyjRHD1JZc"}}]},{"text":"; ","type":"text"},{"text":"Jiang et al., 2014","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2014&filename=ZYEZ201401030&uniplatform=OVERSEAS_EN&v=dDEujMSTuoUKuxjWY3NDgkC2bBVPJMWjgpP2wUu4nbsMsSy_wry3J1BNMkmb2t9y"}}]},{"text":"; ","type":"text"},{"text":"Chen et al., 2013","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDHIS2&filename=ZSFX201324085&uniplatform=OVERSEAS_EN&v=Rb_71hGSOuTZiOwwlXBQUjcLn-2Tg-rPQuKodcc56s81tdsbTVdf0uU5ZtKrZuhz"}}]},{"text":"; ","type":"text"},{"text":"Shi et al., 2013","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2013&filename=YYCY201328037&uniplatform=OVERSEAS_EN&v=99Yt_KZ-2sFJa846PgxIkX3lSzQoO4Cm9wmt9QIQBrKuz2TnRp4n7nUTnwIM60Zv"}}]},{"text":"; ","type":"text"},{"text":"Dong et al., 2012","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2012&filename=REND201206067&uniplatform=OVERSEAS_EN&v=QDst1cFlpabCzMFgxecrorMiajbljcJN5vppblqyVSjZmrjmr-_w8zLWHXKOO8A6"}}]},{"text":"; ","type":"text"},{"text":"Mao, 2009","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2009&filename=BHON200906067&uniplatform=OVERSEAS_EN&v=Qxde36wdIJjCYu5G8q5EmVBzgSnj3GVLyGSD6-5xowIGwUsrBFhTTuV0MuYwraFy"}}]},{"text":"; ","type":"text"},{"text":"Zhang et al., 2009","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2009&filename=ZYEK200905044&uniplatform=OVERSEAS_EN&v=zJpl-eRQQhOmwX4HZJnuh8hMr-wLqe_T7nSsi4yg9whVxv-5rr0TMbbtpBEOq_mn"}}]},{"text":"; ","type":"text"},{"text":"Ding et al., 2007","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2007&filename=ZMYX200706018&uniplatform=OVERSEAS_EN&v=0OU0Mpwim8HYXE42x5zuLFsF58p17wpEuZKDyRtj0f1kQ-ob1xZ6X5gQuoC7D-v5"}}]},{"text":"; ","type":"text"},{"text":"Zhang & Zhang, 2017","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2017&filename=ZYLY201708039&uniplatform=OVERSEAS_EN&v=Y37lz09OtwWYmmX-2GpOIG-lla-HK6X9uCAQI9LJDHcIJew36XKcnoBtWBYzHean"}}]},{"text":"; ","type":"text"},{"text":"Zhu et al., 2003b","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2003&filename=NXYX200306037&uniplatform=OVERSEAS_EN&v=pHwC6LDxNlJcSJAVIQeCwpw4TZW_3sl7yXsb7HMagP-FT1drCiTMXu0T-eZk946X"}}]},{"text":"; ","type":"text"},{"text":"Wang, 2020","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2020&filename=YLYS202013055&uniplatform=OVERSEAS_EN&v=R7QYmrSoaiGfbWCj3Y8lOM0-7mfN8ssQaCQQ1QGk32UZaX3tKbKpPVvqfN2tmG1Q"}}]},{"text":"; ","type":"text"},{"text":"Li, 2010","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CMFD&dbname=CMFD2012&filename=1011048994.nh&uniplatform=OVERSEAS_EN&v=j6t2dXLbg7KP-PnV6JacsGu4D17Z61PiZvkM-CCb1mA0rsXmaP61f6UK84A5tjYu"}}]},{"text":"; ","type":"text"},{"text":"Wang, 2009","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2009&filename=XDZY200905035&uniplatform=OVERSEAS_EN&v=mEzWzuNoumoA2eHPUz0z4GyJOPzOKU4KdPZ-gbP0KXGas-kyaFBwSrCxLNQV4NpY"}}]},{"text":"; ","type":"text"},{"text":"Yu et al., 2020","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2021&filename=ZYAO202012022&uniplatform=OVERSEAS_EN&v=_7t174iEjaM39UXjwD-1lP_tfmvtfLBGZ9UumrfHdMCcKq5GbaN2Dbt_LpbDEVFs"}}]},{"text":"; ","type":"text"},{"text":"Hu et al., 2008","type":"text","marks":[{"type":"link","attrs":{"href":"https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2008&filename=YLZL200801023&uniplatform=NZKPT&v=cw8LR2ApAgJX8tuZziVYyGA3AxzJ4Utq6T9l9dle6nubrpfvbrJGOg0Uyn-d5ZQq"}}]}]},{"type":"paragraph","content":[{"text":"Conflict: ","type":"text"},{"text":"Kirman, 1961","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/10.1111/jir.1961.5.2.108"}}]}]},{"type":"paragraph","content":[{"text":"Only abstract (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"Many studies ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"(≥10)","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":" in the same direction: +0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Conflict (no better than other treatments; desmopressin in Jin and Yang; alarm in Tong): 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2008","type":"text","marks":[{"type":"link","attrs":{"href":"https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2008&filename=YLZL200801023&uniplatform=NZKPT&v=cw8LR2ApAgJX8tuZziVYyGA3AxzJ4Utq6T9l9dle6nubrpfvbrJGOg0Uyn-d5ZQq"}}]},{"text":"; ","type":"text"},{"text":"Ma et al., 2020","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2020&filename=MZMJ202013023&uniplatform=OVERSEAS_EN&v=B1Ok3XNd1I0LxUk8E9s-104EjfRiBXEXYpoWGr9XV6N3ptBJLM2-GbeUQiuhsUbI"}}]},{"text":";","type":"text"},{"text":" ","type":"text"},{"text":"Wang, 2020","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2020&filename=YLYS202013055&uniplatform=OVERSEAS_EN&v=R7QYmrSoaiGfbWCj3Y8lOM0-7mfN8ssQaCQQ1QGk32UZaX3tKbKpPVvqfN2tmG1Q"}}]}]},{"type":"paragraph","content":[{"text":"Only abstract (all trials): 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with","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":" CPH group vs. 19/28 ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"(68%) with ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"conventional treatment.","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Huang n","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"europathy: ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"4/43 (9%) in CPH vs. ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"11/42 (26%) in 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2006","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2006&filename=SYYJ200617060&uniplatform=OVERSEAS_EN&v=BJwTM9pdB-r17EFSwdYqg3lKxzPGcSelb-N8aIkMGU-HqQC9W1dilkfcvfcV5PZH"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Li, 2009","type":"text","marks":[{"type":"link","attrs":{"href":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XYWS200917021.htm"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Single blinded (Huang) and no mention (Li): -0.25","type":"text"},{"type":"hardBreak"},{"text":"Not randomized mentioned (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"Only abstract (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"Too high weighted score for only two abstracts: 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1986","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/https://doi.org/10.1002/gps.930010204"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"In Pek test II, which assess intelligence and cognition, CPH negative score, while the placebo no effect (-19.4% vs. +3.4%; p=0.03).","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"No info from RCTs: -0.75","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"No blinding mentioned (all trials): -0.25","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Conflict: 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depression","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"4eb18074-13ab-46f4-8792-aad972eea937"}}]},{"type":"paragraph","content":[{"text":"In Xing, 71.4% were markedly improved with CPH","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"In Bian CPH combined with fluoxetine is the same as fluoxetine alone","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"*Tang & Zhou; Qiu & Zhang","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"26e00fef-0a28-489c-b41c-a820f269e219"}}]},{"type":"paragraph","content":[{"text":"In Xing 92.9% of the patients","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"In Bian 84% (21/25) ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"for CPH combined with fluoxetine ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"vs. 74% (17/23) fluoxetine alone","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"*Tang & Zhou; Qiu & 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1996","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD9697&filename=LCJS606.006&uniplatform=OVERSEAS_EN&v=GnjdlYcZ-864_jN4N0y9UFSLGguoMRHF4AP1FNv6yQnHYzmebaLK0U7g1sT2URd2"}}]},{"text":"; ","type":"text"},{"text":"Tang & Zhou, 2006","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2006&filename=LCSX200603005&uniplatform=OVERSEA&v=hiUYMYP-eq0IsD_lXDEtfsXePvzEF6xOzz30QJesB-SQPcNNKHMCCpHvsUELpi0I"}}]}]},{"type":"paragraph","content":[{"text":"3 Observational: ","type":"text"},{"text":"Qiu & Zhang, 2003","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2003&filename=MEDI200309036&uniplatform=OVERSEAS_EN&v=bZAxfmiEzZbRKWY9SQOY2vDrL6V21xaRNlA5JSqENCF-YYjWMW1GKgJ6E60TJWly"}}]}]},{"type":"paragraph","content":[{"text":"Conflict: ","type":"text"},{"text":"Bian et 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level","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"f9a6a395-f999-432d-b455-4a8608e2c47f"}}]},{"type":"paragraph","content":[{"text":"In Zhang GCS 42% higher than control (13 vs. 9; from moderate to mild)","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"In Bassem, increased by 26% (from 12 on ICU admission to 15 on discharge at a median of 8 days, which is from moderate to mild)","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"*Cooperation Study Group; Ma; Lu; Gao; Gao; 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GCS unchanged in only 6/300 patients (2.0%)","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"*Cooperation Study Group; Ma; Lu; Gao; Gao; Umlauf","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; Zhang","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[188.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"1b1a3339-9ed9-4f64-8472-e93d9912376c"}}]},{"type":"paragraph","content":[{"text":"In Lu GCS remained elevated on days 7, 14 & 28 when the treatment was for 14 days","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"it is curative, recover 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RCT: ","type":"text"},{"text":"Cooperation Study Group on Acute Cerebrovascular Diseases, 1978","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.cochranelibrary.com/central/doi/10.1002/central/CN-00268085/full"}}]},{"text":"; ","type":"text"},{"text":"Zhang, 2018b","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2018&filename=ZYYY201809041&uniplatform=OVERSEAS_EN&v=-QjMR8ji7j8-h8vY7KPno9CtF1ONDZoD6_DBgAXPVbc9GZzduTILoULz_BdeiclB"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text"},{"text":"Ma, 2018","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2019&filename=ZYYS201812046&uniplatform=OVERSEAS_EN&v=dFnDqUvK6CGIh_K7uIxvbHZPvjNeoifai6fcHJlAL_h6rA4vxA1emGjkrXXn8wcp"}}]},{"text":"; ","type":"text"},{"text":"Lu et al., 2007","type":"text","marks":[{"type":"link","attrs":{"href":"https://en.cnki.com.cn/Article_en/CJFDTotal-YXFY200704012.htm"}}]},{"text":"; ","type":"text"},{"text":"Gao et al., 2008","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2008&filename=YYCY200816042&uniplatform=OVERSEAS_EN&v=3Ie7QMS5iTDeRhA9w9uc-Hue-TBmu3fD60SnXullaXWCq2CUKRSpkw3T3lrWmNJ9"}}]},{"text":"; ","type":"text"},{"text":"Gao et al., 2006","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2006&filename=GWHH200605015&uniplatform=OVERSEAS_EN&v=t1zyCOdrpdLiFET9hJepgpWVap9YU8NGnaxrmkYamYdM7ZqISWhQxHDSPKi-BfSE"}}]}]},{"type":"paragraph","content":[{"text":"2 Open-label: ","type":"text"},{"text":"Umlauf et al., 1983","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/10.1016/0013-4694(83)92377-5"}}]}]},{"type":"paragraph","content":[{"text":"3 Observational: ","type":"text"},{"text":"Bassem et al., 2018","type":"text","marks":[{"type":"link","attrs":{"href":"http://article.sapub.org/10.5923.j.ijim.20180704.01.html"}}]}]},{"type":"paragraph","content":[{"text":"Conflict: ","type":"text"},{"text":"Cooperation Study Group on Acute Cerebrovascular Diseases, 1978","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.cochranelibrary.com/central/doi/10.1002/central/CN-00268085/full"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}},{"type":"link","attrs":{"href":"https://www.cochranelibrary.com/central/doi/10.1002/central/CN-00268085/full"}}]},{"text":"Hasegawa et al., 1976","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.cochranelibrary.com/central/doi/10.1002/central/CN-00267840/full"}}]}]},{"type":"paragraph","content":[{"text":"(CPH superior to control in cerebral hemorrhage, but inferior to control in cerebral infarction)","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Data from not blinded trials (except Cooperation Study Group that is also in conflicts): -0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Only abstract (except Bassem that is observational): -0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Conflict: 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TBI","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"036b66b6-fac9-4ea0-b938-c46aadec524f"}}]},{"type":"paragraph","content":[{"text":"*","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"d38e1050-7996-490f-afa2-91cf3f1f3d0c"}}]},{"type":"paragraph","content":[{"text":"In Han ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"18 cases cured (69%), 6 effective, 1 improved and 1 ineffective","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"In Xing, ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"11/13 cases significant curative effect","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]},{"type":"paragraph","content":[{"text":"*Ma","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[188.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"43f79407-8da1-4325-91b1-cde94f0c473e"}}]},{"type":"paragraph","content":[{"text":"recovery from trauma should be curative","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[153.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"green","style":"bold","text":"3","localId":"02a6fb0c-d2ea-45a9-951b-fbd8ef30ce40"}}]},{"type":"paragraph","content":[{"text":"can be 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","type":"text"},{"text":"Guo et al., 2011","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2011&filename=YYXK201117146&uniplatform=OVERSEAS_EN&v=dGiwO7Vt3nFTgtU_whOwqYDd6OqSF1nOjYqXV2O1vjIhpUmUnkbjnlTbs0l1_jzR"}}]}]},{"type":"paragraph","content":[{"text":"3 Observational: ","type":"text"},{"text":"Han, 2005","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2005&filename=HNSJ200506084&uniplatform=OVERSEAS_EN&v=utbKcIl2nWcgHs2jyXcfFcjk_mb6lvv1mvMNyTTlO0QIRCtDKxzoYfkzkcdkITbd"}}]},{"text":"; ","type":"text"},{"text":"Xing & Yang, 1991","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD9093&filename=SXYZ199112007&uniplatform=OVERSEAS_EN&v=5tgoLhsnB5D7ukrS1P1p1x614SBx3xqupsIAw6fIdU6xyQhOV4tHXraOUJgWpesW"}}]}]},{"type":"paragraph","content":[{"text":"Conflict: ","type":"text"},{"text":"Itoh et al., 1968","type":"text","marks":[{"type":"link","attrs":{"href":"https://sci-hub.se/https:/doi.org/10.1111/j.1440-1819.1968.tb01307.x"}}]}]},{"type":"paragraph","content":[{"text":"Data from Observational (Han; Xing): -1","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Only abstract (all trials): -0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"Conflict: 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enuresis","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"9a0223b0-c7e9-424a-a93c-883fbc879879"}}]},{"type":"paragraph","content":[{"text":"*","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[156.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"871f121f-a14a-4cbd-a00b-1e479156225f"}}]},{"type":"paragraph","content":[{"text":"In Bai TCM 89% vs. CPH 75.5%","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Zhu: 77.5% improved (CPH + salvia) vs.32.5% salvia alone ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Zhou: 73.3% CPH vs. 90.0% in TCM","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Yan: all improved","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"*Bian; Zhu & Ren; Zhao","type":"text"}]},{"type":"paragraph","content":[{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[188.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"ae1b7d99-a12e-44fb-b5c6-4adfbc5738bd"}}]},{"type":"paragraph","content":[{"text":"no follow up post-treatment","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[153.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"850a5751-b5b8-46a7-b17a-ed84694f87e9"}}]},{"type":"paragraph","content":[{"text":"in adult enuresis may be be persistent and affect QOL more than pediatric","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[98.0]},"content":[{"type":"paragraph","content":[{"text":"5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[77.0]},"content":[{"type":"paragraph","content":[{"text":"1.25","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[68.0]},"content":[{"type":"paragraph","content":[{"text":"+1","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[332.0]},"content":[{"type":"paragraph","content":[{"text":"1 RCT: ","type":"text"},{"text":"Zhu et al., 2003a","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2003&filename=XYYL200309001&uniplatform=OVERSEAS_EN&v=iRb9cGieVKX20tYBw0oIQb8k8WZpxHCA6iIz79iLtIA6--Rx2-iIIeozrTozZa1Z"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}},{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2003&filename=XYYL200309001&uniplatform=OVERSEAS_EN&v=iRb9cGieVKX20tYBw0oIQb8k8WZpxHCA6iIz79iLtIA6--Rx2-iIIeozrTozZa1Z"}}]},{"text":"Bian et al., 2004","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2004&filename=SYIY200409013&uniplatform=OVERSEAS_EN&v=2MoitBogwdSZ8Al6nhaTkMRFdYf68TMzFSMAW2WV8qdJCGUVbunG9fqJo6atKnq9"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"2 Comparative: ","type":"text"},{"text":"Zhou et al., 2013","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFDHIS2&filename=REND201312017&uniplatform=OVERSEAS_EN&v=TMcw5uC-SCNFS4Bzy34ePQF-OAeaCYMOn2Q87bVwrPULaROMOtXILxDgB_LWJ033"}}]},{"text":"; ","type":"text"},{"text":"Bai et al., 2002","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD2002&filename=ZJZH200212011&uniplatform=OVERSEAS_EN&v=p4xqomBjAIMPjbj-UXV3Q_Z9_HBmlbSTv3QP2-V1QJPixCFmqLoQqeJMR82rCcys"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"3 Observational: ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Zhu & Ren, 1997","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD9697&filename=LCSX199702015&uniplatform=OVERSEAS_EN&v=PlqvKH_ZSHfZ2r9o6u6gi5icGj2AD3kQd0mDLC92mmkOuBnaaoble1GgvxxG_zFB"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Yan, 1990","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFD&dbname=CJFD9093&filename=ZSJJ199001039&uniplatform=OVERSEAS_EN&v=Ce85DnDKroBrJCqnh8pW4lcdstGMeIHJXNxqK5DFY3scIJq9Th60d2P-hRSdkyUd"}},{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"; ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Zhao, 2004","type":"text","marks":[{"type":"link","attrs":{"href":"https://oversea.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFD9908&filename=ZHYX200411002219&uniplatform=OVERSEAS_EN&v=700WU0tRjVobslUrI-F7LweDjPSTm1aZFX48O2Z6cKd2TC4n0mrC6TDuiB8HEENO1Z-PyEItJbA%3d"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Only abstract (all trials): -0.5","type":"text"},{"type":"hardBreak"},{"text":"No numerical data from RCT (only Bai provides data): -0.75","type":"text"},{"type":"hardBreak"},{"text":"TCM better than CPH: -0.5","type":"text"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[109.0]},"content":[{"type":"paragraph","content":[{"text":"2.25-1.75","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"=0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]}]}]},{"type":"paragraph","content":[{"text":"*no information 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and","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"acatalasemia","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[149.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"771dd52b-8ad8-4b37-831b-e766737fb09e"}}]},{"type":"paragraph","content":[{"text":"unknown","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[125.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"yellow","style":"bold","text":"2","localId":"e8a2a1bd-0d52-41d6-a51a-b26b9195aa62"}}]},{"type":"paragraph","content":[{"text":"need to do blood test to detect it","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":" ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[146.0]},"content":[{"type":"paragraph","content":[{"type":"status","attrs":{"color":"neutral","style":"bold","text":"1","localId":"9a911467-e1a4-4cdc-a58c-078fa0f695f8"}}]},{"type":"paragraph","content":[{"text":"test for G6PD deficiency before treatment","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[64.0]},"content":[{"type":"paragraph","content":[{"text":"5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[78.0]},"content":[{"type":"paragraph","content":[{"text":"1.25","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[70.0]},"content":[{"type":"paragraph","content":[{"text":"-1","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[248.0]},"content":[{"type":"paragraph","content":[{"text":"3 Pre-clinical: ","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"text":"Alicigüzel et al., 2001","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.tandfonline.com/doi/pdf/10.1179/135100001101536256?needAccess=true"}},{"type":"textColor","attrs":{"color":"#000000"}}]}]},{"type":"paragraph","content":[{"text":"Single study: +0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"type":"hardBreak"},{"type":"hardBreak"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":[105.0]},"content":[{"type":"paragraph","content":[{"text":"-0.25+0.5","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"},{"text":"=0","type":"text","marks":[{"type":"textColor","attrs":{"color":"#000000"}}]},{"type":"hardBreak"}]}]}]}]},{"type":"paragraph","content":[{"text":"*no information could be extracted from the trials","type":"text"}]}]},{"type":"paragraph","content":[{"type":"hardBreak"}]}],"version":1}

Centrophenoxine - Supplementary Data

Table 5: Benefit assessment